PIPA5102915
KSR1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102915-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5102915 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
KSR1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KSR1
Gene Alias
AW492498; B-KSR1; CAP kinase; D11Bhm183e; D11Bhm184e; hb; HB protein; kinase KSR1; Kinase suppressor of Ras 1; Ksr; KSR1; mKSR1; OTTHUMP00000162931; protein Hb; RSU2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16706, 360573, 8844
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q61097, Q8IVT5
Gene Symbols
KSR1
Immunogen
A synthesized peptide derived from human KSR1(Accession Q8IVT5), corresponding to amino acid residues R544-R594.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total KSR1
- Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases
- Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126)
- Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP
- Its kinase activity is unsure
- Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown
- [UniProt]