Factor XIIIa Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102931-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5102931 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Factor XIIIa
Classification
Polyclonal
Conjugate
Unconjugated
Gene
F13A1
Gene Alias
1200014I03Rik; AI462306; bA525O21.1 (coagulation factor XIII, A1 polypeptide); coagulation factor XIII A chain; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; coagulation factor XIII, A1 subunit; coagulation factor XIII, alpha subunit; coagulation factor XIIIa; F13A; F13a1; factor viiia; Factor XIIIA; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; protein-glutamine gamma-glutamyltransferase A chain; RP11-232H4.1; TGase; transglutaminase A chain; transglutaminase. plasma
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2162
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P00488
Gene Symbols
F13A1
Immunogen
A synthesized peptide derived from human F13A1(Accession P00488), corresponding to amino acid residues W376-Q426.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total F13A1
- This gene encodes the coagulation factor XIII A subunit
- Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade
- Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits
- The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules
- Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin
- Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII
- This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot
- It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin
- Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone
- These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.