PIPA5103624
ATXN7L3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103624-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5103624 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
ATXN7L3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ATXN7L3
Gene Alias
AT7L3; ataxin 7 like 3; ataxin 7-like 3; ataxin-7-like protein 3; ATXN7L3; DKFZp761G2113; E030022H21Rik; SAGA-associated factor 11 homolog
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
217218, 56970
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
A2AWT3, Q14CW9
Gene Symbols
ATXN7L3
Immunogen
A synthesized peptide derived from human ATXN7L3(Accession Q14CW9), corresponding to amino acid residues S112-N162.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total ATXN7L3
- Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination
- Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879)
- The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription
- Required for nuclear receptor-mediated transactivation
- Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972)
- Regulates H2B monoubiquitination (H2Bub1) levels
- Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583)
- [UniProt]