CHD8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103741-Each-of-1 | In Stock | ₹ 45,345.50 |
PIPA5103741 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,345.50
GST (18%): ₹ 8,162.19
Total Price: ₹ 53,507.69
Antigen
CHD8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Chd8
Gene Alias
5830451P18Rik; ATP-dependent helicase CHD8; AU015341; AUTS18; Axis duplication inhibitor; beta-catenin binding protein; CHD8; CHD-8; chromodomain helicase DNA binding protein 8; chromodomain-helicase-DNA-binding protein 8; Duplin; helicase with SNF2 domain 1; HELSNF1; Kiaa1564; mKIAA1564
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
57680, 65027, 67772
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q09XV5, Q9HCK8, Q9JIX5
Gene Symbols
Chd8
Immunogen
A synthesized peptide derived from human CHD8(Accession Q9HCK8), corresponding to amino acid residues R2334-V2384.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total CHD8
- DNA helicase that acts as a chromatin remodeling factor and regulates transcription
- Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes
- Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity
- Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity
- Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes
- Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF
- Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity
- Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.