CCDC8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103756-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5103756 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CCDC8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CCDC8
Gene Alias
3M3; CCDC8; coiled-coil domain containing 8; coiled-coil domain containing protein 8; coiled-coil domain-containing protein 8; Coiled-coil domain-containing protein 8 homolog; ENSMUSG00000041117; p90; PPP1R20; probable Coiled-coil domain-containing protein 8; protein phosphatase 1, regulatory subunit 20
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
434130, 83987
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
D3YZV8, Q9H0W5
Gene Symbols
CCDC8
Immunogen
A synthesized peptide derived from human CCDC8(Accession Q9H0W5), corresponding to amino acid residues F44-V94.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total CCDC8
- The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC
- The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer
- The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation
- The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation
- The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes
- This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.