PIPA5109495
CD19 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109495-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5109495 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CD19
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cd19
Gene Alias
AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Cd19; CD19 antigen; CD19 molecule; CVID3; differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12478, 365367, 930
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
0.36 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
P15391, P25918
Gene Symbols
Cd19
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 457-556 of human CD19 (NP_0017613)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: NAESYENEDE ELTQPVARTM DFLSPHGSAW DPSREATSLG SQSYEDMRGI LYAAPQLRSI RGQPGPNHEE DADSYENMDN PDGPDPAWGG GGRMGTWSTR CD19 is a member of the immunoglobulin superfamily and has two Ig like domains
- The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains
- CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage
- Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen
- The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias
- Lymphocytes proliferate and differentiate in response to various concentrations of different antigens
- The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors
- CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation
- Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge
- Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.