PIPA5109592
CRX Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109592-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5109592 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CRX
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Crx
Gene Alias
Cone rod homeobox; cone-rod homeobox; cone-rod homeobox containing; cone-rod homeobox protein; CORD 2; CORD2; CRD; CRX; Crx1; LCA 7; LCA7; orthodenticle homeobox 3; OTX; OTX 3; OTX3
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12951
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1.08 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
O54751
Gene Symbols
Crx
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CRX (NP_0005451)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: QQKQQQQPPG GQAKARPAKR KAGTSPRPST DVCPDPLGIS DSYSPPLPGP SGSPTTAVAT VSIWSPASES PLPEAQRAGL VASGPSLTSA PYAMTYAPAS A The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin
- Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes
- The CRX gene is also expressed in the pinealocytes of the pineal gland and may regulate pineal circadian activity by controling the expression of melatonin synthesis genes
- Furthermore, CRX(-) mice exhibit disruption of circadian rhythms
- The human CRX gene maps to chromosome 19q13.3 within the region of the cone-rod dystrophy-2 locus (CORD2)
- Mutations in the CRX gene are implicated in the visual pathologies of CORD, Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP)
- All characterized CRX gene mutations produce disease in heterozygotes although there is no known correlation between the pathologic phenotype and genetic mutation
- Missense mutations of the CRX gene affect the homeobox domain, whereas frameshift mutations affect the OTX domain.