PIPA5109593
CRY2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109593-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5109593 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CRY2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CRY2
Gene Alias
AV006279; CRY2; cryptochrome 2 (photolyase-like); cryptochrome circadian clock 2; cryptochrome-2; D130054K12Rik; growth-inhibiting protein 37; HCRY2; Kiaa0658; PHLL2
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1408, 170917
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.56 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q49AN0, Q923I8
Gene Symbols
CRY2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human CRY2 (NP_0669403)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: EIQENHDETY GVPSLEELGF PTEGLGPAVW QGGETEALAR LDKHLERKAW VANYERPRMN ANSLLASPTG LSPYLRFGCL SCRLFYYRLW DLYKKVKRNS T Various biochemical, physiological and behavioral processes display circadian rhythms controlled by an internal biological clock
- The central "egears"e driving this clock appear to be composed of an autoregulatory transcription/post translation-based feedback loop
- Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases
- In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function
- Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM
- They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors
- Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively
- It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases
- A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.