CYP11A1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109610-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5109610 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CYP11A1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CYP11A1
Gene Alias
cholesterol 20-22 desmolase; cholesterol desmolase; cholesterol monooxygenase (side-chain cleaving); cholesterol side chain cleavage; cholesterol side-chain cleavage cytochrome P450; cholesterol side-chain cleavage enzyme, mitochondrial; cscc; Cyp11a; Cyp11a1; Cyp11a-1; CYPXIA1; cytochrome P450 11a cholesterol side chain cleavage; cytochrome P450 11A1; cytochrome P450 family 11 subfamily A member 1; cytochrome P450 family 11 subfamily A polypeptide 1; cytochrome P450 side-chain cleavage enzyme; cytochrome P450 subfamily 11A; cytochrome P450(scc); cytochrome P450, 11a, cholesterol side-chain cleavage; cytochrome P450, family 11, subfamily A, polypeptide 1; cytochrome P450, subfamily XIA (cholesterol side chain cleavage); cytochrome P450C11A1; D9Ertd411e; P450(scc); P450scc; Scc; steroid 20-22-lyase
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13070, 1583, 29680
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.93 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
P05108, P14137, Q9QZ82
Gene Symbols
CYP11A1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 40-320 of human CYP11A1 (NP_0007722)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: ISTRSPRPFN EIPSPGDNGW LNLYHFWRET GTHKVHLHHV QNFQKYGPIY REKLGNVESV YVIDPEDVAL LFKSEGPNPE RFLIPPWVAY HQYYQRPIGV LLKKSAAWKK DRVALNQEVM APEATKNFLP LLDAVSRDFV SVLHRRIKKA GSGNYSGDIS DDLFRFAFES ITNVIFGERQ GMLEEVVNPE AQRFIDAIYQ MFHTSVPMLN LPPDLFRLFR TKTWKDHVAA WDVIFSKADI YTQNFYWELR QKGSVHHDYR GILYRLLGDS KMSFEDIKAN V CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of cAMP signal
- CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, which is determined by hormonal control of cholesterol availability
- Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site in the CYP11A1 gene is required for hormonal stimulation
- c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression
- Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in the interstitial cell monolayer, which has a fully functional adenylate cyclase.