PIPA5109614
DAAM1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109614-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5109614 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
DAAM1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DAAM1
Gene Alias
Daam1; Disheveled-associated activator of morphogenesis 1; dishevelled associated activator of morphogenesis 1; I79_021650; KIAA0666
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
208846, 23002, 314212
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.84 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q8BPM0, Q9Y4D1
Gene Symbols
DAAM1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 769-1068 of human DAAM1 (NP_001257449.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: FKKKFAERVA EVKPKVEAIR SGSEEVFRSG ALKQLLEVVL AFGNYMNKGQ RGNAYGFKIS SLNKIADTKS SIDKNITLLH YLITIVENKY PSVLNLNEEL RDIPQAAKVN MTELDKEIST LRSGLKAVET ELEYQKSQPP QPGDKFVSVV SQFITVASFS FSDVEDLLAE AKDLFTKAVK HFGEEAGKIQ PDEFFGIFDQ FLQAVSEAKQ ENENMRKKKE EEERRARMEA QLKEQRERER KMRKAKENSE ESGEFDDLVS ALRSGEVFDK DLSKLKRNRK RITNQMTDSS RERPITKLNF DAAM1 is a diaphanous-related formin first studied as a novel Disheveled binding protein and shown to be crucial for the planar cell polarity pathway in Xenopus
- DAAM1, like other formins, directs nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain
- It is a Rho-regulated formin implicated in neuronal development and regulation of gastrulation
- It was identified as a binding protein of the Wnt receptor-associated protein Disheveled
- It also binds the GTP-bound RhoA and increases its GTP-bound form population in cells
- It exists in an autoinhibited state via intramolecular interactions between its amino-terminal GBD and carboxyl-terminal DAD domains
- Structurally the protein includes a GTPase-binding domain (GBD), a diaphanous inhibitory domain (DID), and a coiled-coil region followed by the FH1, FH2 and C-terminal diaphanous auto-regulatory domain (DAD)
- In humans, the DAAM1 gene is mapped to chromosome 14q23.1.