PNAS4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109629-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5109629 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PNAS4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DESI2
Gene Alias
5830417C01Rik; C1orf121; cb238; CGI-146; DESI; DESI1; desi2; DeSI-2; desumoylating isopeptidase 1; desumoylating isopeptidase 2; Deubiquitinase DESI2; Fam152a; family with sequence similarity 152, member A; fi12d12; hypothetical protein LOC445138; pnas4; PNAS-4; PPPDE peptidase domain containing 1; PPPDE peptidase domain-containing protein 1; Pppde1; Protein FAM152A; sb:cb238; si:ch211-132e22.3; wu:fi12d12; zgc:100860
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51029
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.55 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q9BSY9
Gene Symbols
DESI2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human DESI2 (NP_057160.2).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MGANQLVVLN VYDMYWMNEY TSSIGIGVFH SGIEVYGREF AYGGHPYPFS GIFEISPGNA SELGETFKFK EAVVLGSTDF LEDDIEKIVE ELGKEYKGNA YHLMHKNCNH FSSALSEILC GKEIPRWINR LAYFSSCIPF LQSCLPKEWL TPAALQSSVS QELQDELEEA EDAAASASVA STAAGSRPGR HTKL PNAS4 is a highly conserved protein that shares high homology from plants to animals
- It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4
- PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549
- PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway
- Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine
- At least two isoforms of PNAS4 are known to exist.