PIPA5109631
DGUOK Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109631-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5109631 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
DGUOK
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DGUOK
Gene Alias
deoxyguanosine kinase; deoxyguanosine kinase, mitochondrial; dGK; dGK1; dGK2; dGK3; DGUOK; MTDPS3
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1716, 27369, 297389
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.85 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q16854, Q9QX60
Gene Symbols
DGUOK
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 40-277 of human DGUOK (NP_550438.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: RLSIEGNIAV GKSTFVKLLT KTYPEWHVAT EPVATWQNIQ AAGTQKACTA QSLGNLLDMM YREPARWSYT FQTFSFLSRL KVQLEPFPEK LLQARKPVQI FERSVYSDRY IFAKNLFENG SLSDIEWHIY QDWHSFLLWE FASRITLHGF IYLQASPQVC LKRLYQRARE EEKGIELAYL EQLHGQHEAW LIHKTTKLHF EALMNIPVLV LDVNDDFSEE VTKQEDLMRE VNTFVKNL Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents
- Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders
- These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates
- In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK)
- DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues
- Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS)
- MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number
- Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues.