FAIM3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109706-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5109706 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
FAIM3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Fcmr
Gene Alias
1810037B05Rik; Faim3; Fas apoptotic inhibitory molecule 3; Fc fragment of IgM receptor; Fc mu receptor; FCMR; FcmuR; IgM Fc fragment receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso; TOSO
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
548326, 69169, 9214
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.69 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
A1KXC4, O60667, Q5M871
Gene Symbols
Fcmr
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human FAIM3 (NP_005440.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: RILPEVKVEG ELGGSVTIKC PLPEMHVRIY LCREMAGSGT CGTVVSTTNF IKAEYKGRVT LKQYPRKNLF LVEVTQLTES DSGVYACGAG MNTDRGKTQK VTLNVHSEYE PSWEEQPMPE TPKWFHLPYL FQMPAYASSS KFVTRVTTPA QRGKVPPVHH SSPTTQITHR PRVSRASSVA GDKPRTFLPS TTASKISALE GLLKPQTPSY NHHTRLHRQR ALDYGSQSGR EGQG Apoptosis is an important process by which normal tissue homeostasis and function are maintained
- One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand
- This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7
- Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis
- Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.