GATM Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109756-Each-of-1 | In Stock | ₹ 46,858.50 |
PIPA5109756 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,858.50
GST (18%): ₹ 8,434.53
Total Price: ₹ 55,293.03
Antigen
GATM
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GATM
Gene Alias
1810003P21Rik; Agat; AI314789; AT; CCDS3; GATM; glycine amidinotransferase; glycine amidinotransferase (L-arginine:glycine amidinotransferase); glycine amidinotransferase, mitochondrial; L-arginine: glycine amidinotransferase; l-arginine:glycine amidinotransferase; testicular secretory protein Li 19; transamidinase
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2628, 67092, 81660
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.43 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
P50440, P50442, Q9D964
Gene Symbols
GATM
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 38-423 of human GATM (NP_0014731?)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: STQAATASSR NSCAADDKAT EPLPKDCPVS SYNEWDPLEE VIVGRAENAC VPPFTIEVKA NTYEKYWPFY QKQGGHYFPK DHLKKAVAEI EEMCNILKTE GVTVRRPDPI DWSLKYKTPD FESTGLYSAM PRDILIVVGN EIIEAPMAWR SRFFEYRAYR SIIKDYFHRG AKWTTAPKPT MADELYNQDY PIHSVEDRHK LAAQGKFVTT EFEPCFDAAD FIRAGRDIFA QRSQVTNYLG IEWMRRHLAP DYRVHIISFK DPNPMHIDAT FNIIGPGIVL SNPDRPCHQI DLFKKAGWTI ITPPTPIIPD DHPLWMSSKW LSMNVLMLDE KRVMVDANEV PIQKMFEKLG ITTIKVNIRN ANSLGGGFHC WTCDVRRRGT LQSYLD AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family
- Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and consists of a homodimer, with equilibrium between monomeric and dimeric forms favoring a monomer subunit structure
- AGAT localizes to mitochondrial inner membranes, peripheral membranes and cytoplasm
- Biallelically expressed in placenta and fetal tissues, AGAT is also expressed in brain, heart, liver, lung, salivary gland and skeletal muscle tissue, with high expression in kidney
- AGAT is elevated in the myocardium during heart failure and is decreased in inter-uterine growth restriction (IUGR)-associated placenta
- AGAT catalyzes biosynthesis of guanidinoacetate, the immediate precursor of creatine, which plays a vital role in energy metabolism in muscle tissues
- AGAT defects are associated with arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay or regression, mental retardation, severe disturbance of expressive and cognitive speech and severe depletion of creatine/phosphocreatine in brain
- AGAT may be linked to embryonic and central nervous system development and may function in heart failure response by elevating local creatine synthesis.