PIPA5109871
JAK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5109871-Each-of-1 | In Stock | ₹ 46,858.50 |
PIPA5109871 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,858.50
GST (18%): ₹ 8,434.53
Total Price: ₹ 55,293.03
Antigen
JAK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
JAK1
Gene Alias
AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16451, 3716, 84598
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
3.42 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
P23458, P52332
Gene Symbols
JAK1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human JAK1 (NP_0022182)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: VSEKKPATEV DPTHFEKRFL Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways
- Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1
- JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription
- Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner
- Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.