NUDT16 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5110049-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5110049 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
NUDT16
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NUDT16
Gene Alias
2310041H06Rik; 2810047L04Rik; 2900006H04Rik; AI851783; IDP phosphatase; IDPase; inosine diphosphate phosphatase; LOC100718706; m7GpppN-mRNA hydrolase; nucleoside diphosphate-linked moiety X motif 16; nudix; nudix (nucleoside diphosphate linked moiety X)-type motif 16; nudix hydrolase 16; Nudix motif 16; nudix-type motif 16; NUDT16; RGD1311387; testicular tissue protein Li 129; U8 snoRNA-binding protein H29K; U8 snoRNA-decapping enzyme
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
131870, 75686
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.56 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q6P3D0, Q96DE0
Gene Symbols
NUDT16
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 60-130 of human NUDT16 (NP_689608.2).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: GFVDTQDRSL EDGLNRELRE ELGEAAAAFR VERTDYRSSH VGSGPRVVAH FYAKRLTLEE LLAVEAGATR A RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner
- Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA
- Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA
- Catalyzes also the cleavage of the cap structure on mRNAs
- Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG)
- Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies
- Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species
- Binds to the U8 snoRNA; metal is not required for RNA-binding
- May play a role in the regulation of snoRNAs and mRNAs degradation
- Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms (PubMed:20385596, PubMed:26121039)
- The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP (PubMed:20385596)
- Binds strongly to GTP, ITP and XTP
- Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (PubMed:20385596)
- [UniProt]