PHLPP2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5110106-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5110106 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PHLPP2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Phlpp2
Gene Alias
AI481772; C130044A18Rik; GTPase activating protein and VPS9 domains 1; KIAA0931; PH domain and leucine rich repeat protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP2; Phlppl; PHLPP-like; PPM3B; protein phosphatase, Mg2+/Mn2+ dependent 3B; RGD1562857
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23035, 244650, 498949
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
0.68 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q6ZVD8, Q8BXA7
Gene Symbols
Phlpp2
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1250-1323 of human PHLPP2 (NP_0558352)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: DSLNLIEVAT EVPKRKTGYF AAPTQMEPED QFVVPHDLEE EVKEQMKQHQ DSRLEPEPHE EDRTEPPEEF DTAL Protein phosphatase involved in regulation of Akt and PKC signaling
- Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA
- Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes
- Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation
- Also controls the phosphorylation of AKT3
- Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427)
- Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499)
- Inhibits cancer cell proliferation and may act as a tumor suppressor
- Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation
- Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606)
- [UniProt]