PIPA5110262
RAB7B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5110262-Each-of-1 | In Stock | ₹ 45,968.50 |
PIPA5110262 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,968.50
GST (18%): ₹ 8,274.33
Total Price: ₹ 54,242.83
Antigen
RAB7B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RAB7B
Gene Alias
5430435G22Rik; RAB7; Rab7b; RAB7B, member RAS oncogene family; Ras-related protein Rab-7; ras-related protein Rab-7b; RGD1562617; RIKEN cDNA 5430435G22 gene
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
226421, 338382
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
3.04 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q8VEA8, Q96AH8
Gene Symbols
RAB7B
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAB7B (NP_001157994.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Sequence of this protein is as follows: MNPRKKVDLK LIIVGAIGVG KTSLLHQYVH KTFYEEYQTT LGASILSKII ILGDTTLKLQ IWDTGGQERF RSMVSTFYKG SDGCILAFDV TDLESFEALD IWRGDVLAKI VPMEQSYPMV LLGNKIDLAD RKVPQEVAQG WCREKDIPYF EVSAKNDINV VQAFEMLASR ALSRYQSILE NHLTESIKLS PDQSRSRCC Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN)
- Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation
- Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4
- Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1
- Not involved in the regulation of the EGF- and EGFR degradation pathway.