SPRTN Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5110424-Each-of-1 | In Stock | ₹ 45,968.50 |
PIPA5110424 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,968.50
GST (18%): ₹ 8,274.33
Total Price: ₹ 54,242.83
Antigen
SPRTN
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SPRTN
Gene Alias
C1orf124; DDDL1880; dJ876B10.3; DNA damage protein targeting VCP; DNA damage-targeting VCP (p97) adaptor; DVC1; Gm505; PRO4323; protein with SprT-like domain at the N terminus; RGD1559496; spartan; sprT-like domain-containing protein Spartan; SprT-like N-terminal domain; Sprtn; UNQ1880/PRO4323; zinc finger RAD18 domain-containing protein
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
83932
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.63 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q9H040
Gene Symbols
SPRTN
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SPRTN (NP_001010984.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MDDDLMLALR LQEEWNLQEA ERDHAQESLS LVDASWELVD PTPDLQALFV QFNDQFFWGQ LEAVEVKWSV RMTLCAGICS YEGKGGMCSI RLSEPLLKLR PRKDLVETLL HEMIHAYLFV TNNDKDREGH GPEFCKHMHR INSLTGANIT VYHTFHDEVD EYRRHWWRCN GPCQHRPPYY GYVKRATNRE PSAHDYWWAE HQKTCGGTYI KIKEPENYSK KGKGKAKLGK EPVLAAENKG SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis
- SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA
- It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis
- It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.