Synaptotagmin 1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5110747-Each-of-1 | In Stock | ₹ 49,439.50 |
PIPA5110747 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,439.50
GST (18%): ₹ 8,899.11
Total Price: ₹ 58,338.61
Antigen
Synaptotagmin 1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Syt1
Gene Alias
AW124717; DKFZp781D2042; FLJ42519; G630098F17Rik; P65; SV DKFZp781D2042; SV SYT; svp65; Syb1; synaptotagmin 1; synaptotagmin 1 L homeolog; synaptotagmin 2; synaptotagmin I; synaptotagmin I protein; synaptotagmin I variant b; Synaptotagmin II; Synaptotagmin XI; synaptotagmin-1; Synaptotagmin-2; SYT; Syt1; syt1.L; SYT2; SytI; SytII; XELAEV_18022019mg
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6857
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
0.08 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
P21579
Gene Symbols
Syt1
Immunogen
Recombinant Protein corresonding to Human Synaptotagmin 1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: GGKNAINMKD VKDLGKTMKD QALKDDDAET GLTDGEEKEE PKEEEKLGKL QYSLDYDFQN NQLLVGIIQ Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release
- Studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane
- It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size
- Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse
- Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone
- A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported
- Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2
- Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.