PIPA5110834
NLK Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5110834-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA5110834 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
NLK
Classification
Polyclonal
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q9UBE8
Gene Symbols
NLK
Immunogen
Recombinant Protein corresonding to Human NLK
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Conjugate
Unconjugated
Gene
NLK
Gene Alias
AI194375; LAK1; nemo like kinase; nemo-like kinase; NLK; Protein LAK1; RGD1561602; serine/threonine protein kinase NLK; serine/threonine-protein kinase NLK
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51701
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Immunogen sequence: LRGPHKQPSL PVLYTLSSQA THEAVHLLCR MLVFDPSKRI SAKDALAHPY LDEGRLRYHT CMCKCCFSTS TGRVYTSDFE PVTNPKFDDT FEKNLSSVRQ VKEIIHQFIL EQQKGNRVPL CINPQSAAFK SFISSTVAQP S NLK is a serine/threonine kinase involved in signal transduction and cellular communication
- Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2
- Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1
- The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing
- The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs)
- Negative regulator of the canonical Wnt/beta-catenin signaling pathway
- Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1
- Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes
- Negative regulator of the Notch signaling pathway
- Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1
- Negative regulator of the MYB family of transcription factors.