PIPA5111214
Nodal Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5111214-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA5111214 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
Nodal
Classification
Polyclonal
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q96S42
Gene Symbols
NODAL
Immunogen
Recombinant Protein corresonding to Human Nodal
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Conjugate
Unconjugated
Gene
NODAL
Gene Alias
early embryo mesoderm formation; HTX5; MGC138230; Nodal; nodal growth differentiation factor; nodal homolog; Tg.413d; transgenic lethal 413.d
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4838
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Immunogen sequence: PTEGSLAIEI FHQPKPDTEQ ASDSCLERFQ MDLFTVTLSQ VTFSLGSMVL EVTRPLSKWL KHPGALEKQM SRV NODAL is an important TGF-beta family protein in cellular differentiation
- While constitutively expressed in many developing tissues, NODAL is problematically associated with the differentiation and development of many cancers
- The expression of NODAL is regulated by a Notch signaling pathway, which when disrupted contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma
- The abundance of NODAL expression in melanoma can help determine the stage of cancer and metastatic type/progression when tested in IHC
- NODAL interactions with Cripto also predispose toward tumor progression
- Overexpression of NODAL is also associated with preeclamptic placenta.