PHLPP2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5111278-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA5111278 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
PHLPP2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Phlpp2
Gene Alias
AI481772; C130044A18Rik; GTPase activating protein and VPS9 domains 1; KIAA0931; PH domain and leucine rich repeat protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP2; Phlppl; PHLPP-like; PPM3B; protein phosphatase, Mg2+/Mn2+ dependent 3B; RGD1562857
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23035
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry
Concentration
0.10 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q6ZVD8
Gene Symbols
Phlpp2
Immunogen
Recombinant Protein corresonding to Human PHLPP2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT ERPLQIVYDY LSRLGFDDPV RIQEEATNPD LGCMIRFYG Protein phosphatase involved in regulation of Akt and PKC signaling
- Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA
- Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes
- Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation
- Also controls the phosphorylation of AKT3
- Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427)
- Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499)
- Inhibits cancer cell proliferation and may act as a tumor suppressor
- Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation
- Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606)
- [UniProt]