JMJD4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5111363-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA5111363 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
JMJD4
Classification
Polyclonal
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q9H9V9
Gene Symbols
Jmjd4
Immunogen
Recombinant Protein corresonding to Human JMJD4
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry
Conjugate
Unconjugated
Gene
Jmjd4
Gene Alias
2-oxoglutarate- and Fe(II)-dependent oxygenase; 2-oxoglutarate and iron-dependent oxygenase JMJD4; 6430559I23; C4 lysyl hydroxylase; jmjC domain-containing protein 4; JMJD4; jumonji domain containing 4; jumonji domain-containing protein 4; Lysyl-hydroxylase JMJD4; RGD1307186
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
65094
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Immunogen sequence: GVGQAPGRVA FVSEPGAFSY ADFVRGFLLP NLPCVFSSAF TQGWGSRRRW VTPAGRPDFD HLLRTYGDVV VPVANCGVQE YNSNPKEHMT LRDYITYWKE YIQAGYSSPR GCLYLKDWHL CRDFPVEDVF TLPVYFSSDW LNEFWDA Covalent modification of histones plays critical role in regulating chromatin structure and transcription
- While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones
- A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function
- Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate
- Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9)
- Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.