PIPA5111451
DNA ligase IV Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5111451-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA5111451 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
DNA ligase IV
Classification
Polyclonal
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
P49917
Gene Symbols
LIG4
Immunogen
Recombinant Protein corresonding to Human DNA ligase IV
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry
Conjugate
Unconjugated
Gene
LIG4
Gene Alias
5830471N16Rik; DNA joinase; DNA ligase (ATP) 4; DNA ligase 4; DNA ligase IV; DNA repair enzyme; Lig4; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase; tiny
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3981
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Immunogen sequence: PQLERERMAY GIKETMLAKL YIELLNLPRD GKDALKLLNY RTPTGTHGDA GDFAMIAYFV LKPRCLQKGS LTIQQVNDLL DSIASNNSAK RKDLIKKSLL QLITQSSALE QKWLIRMIIK DLKLGVSQQT IFSVFHNDAA ELHNV The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction
- This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ)
- This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK)
- Both XRCC4 and DNA-PK are known to be required for NHEJ
- The crystal structure of the complex formed by this protein and XRCC4 has been resolved
- Defects in this gene are the cause of LIG4 syndrome
- Alternatively spliced transcript variants encoding the same protein have been observed.