GTF3C3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5111643-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA5111643 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
GTF3C3
Classification
Polyclonal
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q9Y5Q9
Gene Symbols
GTF3C3
Immunogen
Recombinant Protein corresonding to Human GTF3C3
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry
Conjugate
Unconjugated
Gene
GTF3C3
Gene Alias
AL022818; general transcription factor 3C polypeptide 3; general transcription factor IIIC subunit 3; general transcription factor IIIC, polypeptide 3; general transcription factor IIIC, polypeptide 3, 102kDa; GTF3C3; im:7136784; LOC553318 protein; TF3C3; TF3C-gamma; TFIIIC 102 kDa subunit; TFIIIC102; TFiiiC2-102; TFIIICgamma; Transcription factor IIIC 102 kDa subunit; Transcription factor IIIC subunit gamma; transcription factor IIIC-gamma subunit
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
9330
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Immunogen sequence: RETKKMMKEK RPRSKLPRAL RGLMGEANIR FARGEREEAI LMCMEIIRQA PLAYEPFSTL AMIYEDQGDM EKSLQFELIA AHLNPSDTEE WVRLAEMSLE QDNIKQAIFC YTKALKYEPT NVRYLWERSS LYEQMGD RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division
- Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes
- The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas
- TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells
- The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells
- In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.