PIPA5112717
SLFN11 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5112717-Each-of-1 | In Stock | ₹ 42,853.50 |
PIPA5112717 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,853.50
GST (18%): ₹ 7,713.63
Total Price: ₹ 50,567.13
Antigen
SLFN11
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SLFN11
Gene Alias
schlafen family member 11; SLFN11; SLFN8/9
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
91607
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Applications
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
3.5 mg/mL
Formulation
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.
Q7Z7L1
Gene Symbols
SLFN11
Immunogen
Recombinant Human Schlafen family member 11 protein (670-821AA)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061)
- Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061)
- Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, μgtimately leading to cell death (PubMed:29395061)
- Acts independently of ATR (PubMed:29395061)
- Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900)
- Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900)
- Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900)
- The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900)
- Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900)
- [UniProt]