PIPA5113652
SPI-B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5113652-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5113652 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
SPI-B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SPIB
Gene Alias
B42b-like; Ets transcription factor Spi-B; Spi-1/PU.1 related; Spib; SPI-B; Spi-B transcription factor; Spi-B transcription factor (Spi-1/PU.1 related); Transcription factor Spi-B
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6689
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.
Q01892
Gene Symbols
SPIB
Immunogen
Synthetic peptide directed towards the middle region of human SPIB
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: WGQQKGNRKR MTYQKLARAL RNYAKTGEIR KVKRKLTYQF DSALLPAVRR For short term use, store at 2-8°C up to 1 week
- For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles
- Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding
- Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP
- As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer
- Two isoforms of Spi-B are reported
- Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication
- Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.