PIPA5114147
RWDD3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114147-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5114147 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
RWDD3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RWDD3
Gene Alias
2510027J23Rik; 3110037C01Rik; AI035684; AI662458; pituitary tumor X2CR1 protein; RSUME; RWD domain containing 3; RWD domain-containing protein 3; RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer; Rwdd3; X2cr1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25950
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.
Q9Y3V2
Gene Symbols
RWDD3
Immunogen
Immunogen sequence: ESLLSEPMVH ELVLWIQQNL RHILSQPETG SGSEKCTFST STTMDDGLWI
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: ESLLSEPMVH ELVLWIQQNL RHILSQPETG SGSEKCTFST STTMDDGLWI For short term use, store at 2-8°C up to 1 week
- For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles
- Predicted homology: Dog: 86%; Guinea Pig: 86%; Human: 100%; Mouse: 79%; Rat: 86% RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals
- RWDD3 increases Ikappa-Beta sumoylation and stability
- In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability
- RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways
- Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization
- Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.