ABCB11 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114800-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5114800 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
ABCB11
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ABCB11
Gene Alias
ABC member 16, MDR/TAP subfamily; ABC16; Abcb11; ATP binding cassette subfamily B member 11; ATP-binding cassette sub-family B member 11; ATP-binding cassette, subfamily B (MDR/TAP), member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, sub-family B, member 11; bile salt export pump; BRIC2; Bsep; Lith1; PFIC2; PFIC-2; PGY4; progressive familial intrahepatic cholestasis 2; sister of P-glycoprotein; sister p-glycoprotein; Spgp
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
27413, 83569, 8647
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.
O70127, O95342, Q9QY30
Gene Symbols
ABCB11
Immunogen
A synthesized peptide derived from human ABCB11(Accession O95342), corresponding to amino acid residues N665-V715.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total ABCB11
- ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes
- It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes
- Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain
- Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2)
- PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity
- Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.