NEK8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116501-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116501 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
NEK8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NEK8
Gene Alias
4632401F23Rik; b2b1449Clo; JCK; juvenile cystic kidney; NEK 8; NEK12A; Nek8; nephrocystin 9; never in mitosis A-related kinase 8; NIMA (never in mitosis gene a)- related kinase 8; NIMA (never in mitosis gene a)-related expressed kinase 8; NIMA related kinase 8; NIMA-family kinase NEK8; NIMA-related expressed kinase 8; NIMA-related kinase 12a; NIMA-related kinase 8; nima-related protein kinase 12a; NimA-related protein kinase 8; NPHP9; RHPD2; Serine/threonine-protein kinase Nek8; serine/thrionine-protein kinase NEK8
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
140859, 284086, 287473
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.3 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
D3ZGQ5, Q86SG6, Q91ZR4
Gene Symbols
NEK8
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 270-390 of human NEK8 (NP_8354641)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: HeLa, Jurkat, K-562, Mouse liver Immunogen sequence: GSVRMRRAEK SVAPSNTGSR TTSVRCRGIP RGPVRPAIPP PLSSVYAWGG GLGTPLRLPM LNTEVVQVAA GRTQKAGVTR SGRLILWEAP PLGAGGGSLL PGAVEQPQPQ FISRFLEGQS G NEK8 serine/threonine kinase or NIMA-related kinase 8 is related to NIMA (never in mitosis, gene A) of Aspergillus nodulins and may play a role in cell cycle progression from G2 to M phase
- NEK8 is part of a complex of ciliary proteins required for renal and cardiovascular development
- NEK8 interacts with polycystin signal transduction pathways and may control the targeting of these ciliary proteins
- Required for renal tubular integrity
- May regulate local cytoskeletal structure in kidney tubule epithelial cells
- May regulate ciliary biogenesis through targeting of proteins to the cilia.Defects in NEK8 are the cause of nephronophthisis type 9 (NPHP9) [MIM:613824]
- NPHP9 is an autosomal recessive disorder resulting in end-stage renal disease
- It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.