RYBP Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116595-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116595 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
RYBP
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Rybp
Gene Alias
2410018J24Rik; AAP1; APAP-1; apoptin-associating protein 1; Death effector domain-associated factor; DEDAF; DED-associated factor; RING1 and YY1 binding protein; RING1 and YY1-binding protein; ring1 interactor RYBP; Rybp; YEAF1; YY1 and E4TF1 associated factor 1; YY1 and E4TF1-associated factor 1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
312603, 56353
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.53 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q8CCI5
Gene Symbols
Rybp
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RYBP (NP_0363663)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Mouse brain, Rat brain Immunogen sequence: PSVTKKNTNK KTKPKSDILK DPPSEANSIQ SANATTKTSE TNHTSRPRLK NVDRSTAQQL AVTVGNVTVI ITDFKEKTRS SSTSSSTVTS SAGSEQQNQS SSGSESTDKG SSRSSTPKGD MSAVNDESF RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development
- PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility
- Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females
- May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites
- Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes
- May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis
- May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1
- May bind to DNA
- May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.