PUMA alpha Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116721-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116721 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PUMA alpha
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BBC3
Gene Alias
BBC3; BCL2 binding component 3; Bcl-2 binding component 3; bcl-2-binding component 3; Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; BH3-only; FLJ42994; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
170770, 27113, 317673
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
2.39 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q80ZG6, Q96PG8, Q99ML1, Q9BXH1
Gene Symbols
BBC3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-131 of human PUMA (NP_0011207131)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: A-549, LO2, HepG2, K562 Immunogen sequence: PGALAGGPTQ AAPGVRGEEE QWAREIGAQL RRMADDLNAQ YERRRQEEQQ RHRPSPWRVL YNLIMGLLPL PRGHRAPEME PN PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53
- The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b
- PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53
- PUMA may be a direct mediator of p53-induced apoptosis
- Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.