SIGLEC8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA511681-Each-of-1 | In Stock | ₹ 48,727.50 |
PIPA511681 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,727.50
GST (18%): ₹ 8,770.95
Total Price: ₹ 57,498.45
Antigen
SIGLEC8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SIGLEC8
Gene Alias
CDw329; MGC59785; SAF2; SAF-2; sialic acid binding Ig like lectin 8; sialic acid binding Ig-like lectin 8; sialic acid-binding Ig-like lectin 8; Sialoadhesin family member 2; Siglec; SIGLEC8; Siglec-8; SIGLEC8L
Host Species
Rabbit
Purification Method
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Regulatory Status
RUO
Gene ID (Entrez)
27181
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
2.0 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q9NYZ4
Gene Symbols
SIGLEC8
Immunogen
KLH conjugated synthetic peptide between 373-406 amino acids from the C-terminal region of human SIGLEC8
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells
- It preferentially binds to alpha2,3-linked sialic acid
- and also binds to alpha2,6-linked sialic acid
- The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface
- SIGLEC8 is expressed specifically on eosinophils
- The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM)
- This motif is involved in downmodulation of cellular responses
- The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1
- The SIGLEC8 gene belongs to the immunoglobulin superfamily.