CD81 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117009-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5117009 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CD81
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CD81
Gene Alias
26 kDa cell surface protein TAPA-1; CD 81 antigen; Cd81; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); CD81 molecule; CVID6; S5.7; Tapa1; Tapa-1; Target of the antiproliferative antibody 1; Tetraspanin28; tetraspanin-28; Tspan28; Tspan-28
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12520, 25621, 975
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.51 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
P35762, P60033, Q62745
Gene Symbols
CD81
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 114-199 of human CD81 (NP_0043471)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Raji, U-87MG Immunogen sequence: VNKDQIAKDV KQFYDQALQQ AVVDDDANNA KAVVKTFHET LDCCGSSTLT ALTTSVLKNN LCPSGSNIIS NLFKEDCHQK IDDLFS CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells
- CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells
- In muscles, CD81 promotes cell fusion and myotube maintenance
- CD81 has been also identified as a receptor for the hepatitis C virus
- Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains
- The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility
- CD81 is a cell surface glycoprotein that is known to complex with integrins
- CD81 appears to promote muscle cell fusion and support myotube maintenance
- CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus
- Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas
- CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.