SCO2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117084-Each-of-1 | In Stock | ₹ 45,968.50 |
PIPA5117084 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,968.50
GST (18%): ₹ 8,274.33
Total Price: ₹ 54,242.83
Antigen
SCO2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Sco2
Gene Alias
CEMCOX1; MYP6; protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2; SCO cytochrome oxidase deficient homolog 2 (yeast); SCO1L; SCO2; SCO2 cytochrome c oxidase assembly protein
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100126824, 9997
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.51 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
O43819, Q8VCL2
Gene Symbols
Sco2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-266 of human SCO2 (NP_0051292)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: 293T, HL-60, SKOV3, Mouse spleen, Mouse brain, Rat spleen Immunogen sequence: GQGDFHLLDH RGRARCKADF RGQWVLMYFG FTHCPDICPD ELEKLVQVVR QLEAEPGLPP VQPVFITVDP ERDDVEAMAR YVQDFHPRLL GLTGSTKQVA QASHSYRVYY NAGPKDEDQD YIVDHSIAIY LLNPDGLFTD YYGRSRSAEQ ISDSVRRHMA AFRSVLS Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane
- Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding
- Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP
- Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.