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PIPA5120502

INSR Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA5120502-Each-of-1 In Stock ₹ 44,811.50

PIPA5120502 - Each of 1

₹ 44,811.50

In Stock

Quantity

1

Base Price: ₹ 44,811.50

GST (18%): ₹ 8,066.07

Total Price: ₹ 52,877.57

Antigen

INSR

Classification

Polyclonal

Conjugate

Unconjugated

Gene

INSR

Gene Alias

4932439J01Rik; CD 220; CD220; CD220 antigen; CD220 beta; CD221; D630014A15Rik; HHF 5; HHF5; IGF-I receptor; INSR; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR1; IR-1; IR-A; IR-B

Host Species

Rabbit

Purification Method

Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

16337, 24954, 3643

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Immunoprecipitation, Western Blot

Concentration

2.3 mg/mL

Formulation

PBS with 50% glycerol and 0.01% thimerosal; pH 7.3

Gene Accession No.

P06213, P15127, P15208

Gene Symbols

INSR

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1281-1382 of human INSR (NP_0001992)

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

Description

  • Positive test controls include: HepG2, HeLa, Mouse brain, Mouse kidney
  • The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein
  • Immunogen sequence: PTFLEIVNLL KDDLHPSFPE VSFFHSEENK APESEELEME FEDMENVPLD RSSHCQREEA GGRDGGSSLG FKRSYEEHIP YTHMNGGKKN GRILTLPRSN PS INSR is a receptor tyrosine kinase
  • Binding of insulin to the extracellular domain of INSR stimulates glucose uptake
  • INSR and IGF-1 receptors share major structural and functional similarity
  • The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR
  • In humans, the INSR gene is located on chromosome 19
  • Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.