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PIPA5120623

Ub-K33 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA5120623-Each-of-1 In Stock ₹ 44,811.50

PIPA5120623 - Each of 1

₹ 44,811.50

In Stock

Quantity

1

Base Price: ₹ 44,811.50

GST (18%): ₹ 8,066.07

Total Price: ₹ 52,877.57

Antigen

Ub-K33

Classification

Polyclonal

Conjugate

Unconjugated

Gene

UBB

Gene Symbols

UBB

Immunogen

A synthetic peptide corresponding to a sequence containing polyubiquitinated protein (K33 linkage)

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

Applications

Dot Blot, Western Blot

Concentration

0.31 mg/mL

Formulation

PBS with 50% glycerol and 0.01% thimerosal; pH 7.3

Gene Accession No.

P0CG47, P0CG49, P0CG51

Host Species

Rabbit

Purification Method

Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

192255, 22187, 7314

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Description

  • Positive test controls include: HeLa, NIH/3T3, RAW264.7, C6
  • Exists either covalently attached to another protein, or free (unanchored)
  • When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains)
  • Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B
  • Linear polymer chains formed via attachment by the initiator Met lead to cell signaling
  • Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed
  • When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling
  • [Uniprot]