CDC37 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5120838-Each-of-1 | In Stock | ₹ 44,811.50 |
PIPA5120838 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,811.50
GST (18%): ₹ 8,066.07
Total Price: ₹ 52,877.57
Antigen
CDC37
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CDC37
Gene Alias
CDC 37; CDC37; CDC37 (cell division cycle 37 S. cerevisiae homolog); CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog; Cdc37 homolog; CDC37 protein; CDC37A; Cdc37p; Cell division control protein 37; cell division cycle 37; cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; p50; P50CDC37; SMO1; YD9489.03; YDR168W
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11140, 12539
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Concentration
0.63 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q16543, Q61081
Gene Symbols
CDC37
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human CDC37 (NP_008996.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive test controls include: Raji, HeLa, HepG2, BT474, HT-1080
- The target is usually found in the following locations: Cytoplasm
- Immunogen sequence: MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK In S
- cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK's)
- Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase
- Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37
- It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90
- Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src
- More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90
- In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.