HLA-C Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5121909-Each-of-1 | In Stock | ₹ 17,346.10 |
PIPA5121909 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 17,346.10
GST (18%): ₹ 3,122.298
Total Price: ₹ 20,468.398
Antigen
HLA-C
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HLA-C
Gene Alias
alpha chain of MHC class II; D6S204; HLA C; HLA class I histocompatibility antigen C alpha chain; HLA class I histocompatibility antigen Cw-1 alpha chain; HLA class I histocompatibility antigen, C alpha chain; HLA class I histocompatibility antigen, Cw-1 alpha chain; HLA class I histocompatibility antigen, Cw-15 alpha chain; HLA class I histocompatibility antigen, Cw-18 alpha chain; HLAC; HLA-C; HLA-C alpha chain; HLA-C alpha chain (HLA-Cw*15v); HLA-C alpha chain for Cw*18GB; HLA-C alpha-chain; HLA-C antigen; HLA-Cw; HLA-Cw*04GB; HLA-Cw*1702; HLA-Cw*18GB; HLA-Cw-1503; HLA-JY3; HLC-C; Human leukocyte antigen C; human leukocyte antigen-C alpha chain; leukocyte antigen C; major histocompatibility antigen HLA-C; major histocompatibility complex, class I, C; MHC; MHC clas I antigen; MHC class 1 antigen; MHC Class I antigen; MHC class I antigen Cw*15; MHC class I antigen Cw*18; MHC class I antigen heavy chain HLA-C; MHC class I histocompatibility antigen; MHC class I molecule; MHC class II a
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3107
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.
P10321
Gene Symbols
HLA-C
Immunogen
Recombinant protein Major Histocompatibility Complex Class I C. The antigen corresponds to amino acid range 48-305 of the target protein.
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- HLA-C belongs to the HLA class I heavy chain paralogues
- This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin)
- The heavy chain is anchored in the membrane
- Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen
- They are expressed in nearly all cells
- The heavy chain is approximately 45 kDa and its gene contains 8 exons
- Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail
- Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule
- Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation
- Over one hundred HLA-C alleles have been described
- HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.