PIPA5142745
ASK Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5142745-Each-of-1 | In Stock | ₹ 40,317.00 |
PIPA5142745 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
ASK
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DBF4
Gene Alias
AA545217; Activator of S phase kinase; ASK; CHIF; chiffon homolog A; Dbf4; DBF4 homolog; DBF4 homolog (S. cerevisiae); DBF4 zinc finger; DBF4 zinc finger A; DBF4A; DBF4-type zinc finger-containing protein 1; MuDBF4; Protein DBF4 homolog A; RGD1305854; ZDBF1; zinc finger, DBF-type containing 1
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
27214, 312046
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q9QZ41
Gene Symbols
DBF4
Immunogen
Peptide with sequence C-DKKRTEYLPAHEDRT.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse, Rat
Form
Liquid
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Description
- Additional Information: This antibody is expected to recognize both reported isoforms (NP_038754.1; NP_001177646.1)
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000
- Activator of S phase kinase (ASK, DBF4) is a novel regulatory subunit of the human Cdc7 kinase complex that plays a pivotal role in G1/S cell cycle transition in mammalian cells
- The increase in Cdc7 kinase activity at the G1/S boundary is at least partly accounted for by the elevated expression of ASK in late G1
- ASK interacts with replication origins in vivo, suggesting that Cdc7 may trigger S phase by directly activating the replication initiation complexes assembled at the origins
- Human ASK protein levels are regulated during the cell cycle with a pattern that matches that of human Cdc7 protein kinase activity
- Human Cdc7-ASK kinase is directly involved in regulating the initiation of DNA replication by targeting MCM2 protein in mammalian cells
- Nuclear localization and chromatin binding of endogenous huCdc7 and GFP-ASK is presumably imported into nuclei through its two nuclear localization signals at telophase, it may require additional signals for chromatin binding, the level of which increases at late G1 ohase
- A functional link may exist between menin, a tumor suppressor protein mutated in multiple endocrine neoplasia type I (MEN1), and ASK in the regulation of cell proliferation.