GABRA6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5142768-Each-of-1 | In Stock | ₹ 40,317.00 |
PIPA5142768 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
GABRA6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Gabra6
Gene Alias
alpha6, GABA subunit A receptor alpha 6, GABA(A) receptor subunit alpha-6, GABA(A) receptor, alpha 6, GABA-A receptor alpha-6 subunit, GABAAR alpha6, GABA-ARalpha6, GABRA 6, Gabra6, Gabra-6, gamma-aminobutyric acid, gamma-aminobutyric acid A receptor, alpha 6, gamma-aminobutyric acid (GABA) A receptor, alpha 6, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6, gamma-aminobutyric acid A receptor, alpha 6, gamma-aminobutyric acid receptor subunit alpha-6, gamma-aminobutyric acid type A receptor alpha6 subunit, subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
2559
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q16445
Gene Symbols
Gabra6
Immunogen
Peptide with sequence ENALGKLEVEGN-C.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A Receptor (GABA-A R) Subtype
- GABA-A Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse
- The GABA-A R is a multimeric subunit complex
- To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified
- Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABA-A Rs sensitive to GABA
- However, coexpression of a gamma-subunit is required for benzodiazepine modulation
- The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor
- Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABA-A R function.