JNK2 beta Polyclonal Antibody, Invitrogen™

Description

• Additional Information: This antibody is expected to recognize isoforms beta1 and beta 2 (NP_620708.1; NP_620709.1)
• This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000
• The protein encoded by this gene is a member of the MAP kinase family
• MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development
• This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli
• It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway
• This gene and MAPK8 are also known as c-Jun N-terminal kinases
• This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells
• Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation
• Several alternatively spliced transcript variants encoding distinct isoforms have been reported
• [provided by RefSeq, Sep 2008]
• MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2
• However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms
• JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.