TRPC6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5142891-Each-of-1 | In Stock | ₹ 40,317.00 |
PIPA5142891 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,317.00
GST (18%): ₹ 7,257.06
Total Price: ₹ 47,574.06
Antigen
TRPC6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Trpc6
Gene Alias
AV025995; bZ1P14.9; calcium entry channel; FLJ11098; FLJ14863; focal segmental glomerulosclerosis 2; FSGS2; HGNC:12338; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; Short transient receptor potential channel 6; short transient receptor potential channel 6; short transient receptor potential channel 6a; si:rp71-1p14.9; transient receptor potential cation channel subfamily C member 6; transient receptor potential cation channel subfamily c member 6a; transient receptor potential cation channel TRPC6; transient receptor potential cation channel, subfamily C, member 6; transient receptor potential cation channel, subfamily C, member 6a; transient receptor potential channel 6; transient receptor potential channel subfamily C member 6; transient receptor protein 6; TRP6; TRP-6; trp6A; TRPC6; trpc6a; Trrp6
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
7225
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q9Y210
Gene Symbols
Trpc6
Immunogen
Peptide with sequence C-KQSSTRSSEDYHLNS.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000
- Trpc6 forms a receptor-activated calcium channel in the cell membrane
- The Trpc6 channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system
- Activation of the Trpc6 channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium
- Defects in the Trpc6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2)
- Further, Trpc6 is a member of the mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "ecanonical TRP"e (TRPC) family
- The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types
- Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors
- When expressed in transfected cells, Trpc6 acts as a non-selective store-independent receptor-activated cation channel
- Trpc6 is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation
- There is increasing evidence that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo
- Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.