PAX2a Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143393-Each-of-1 | In Stock | ₹ 39,427.00 |
PIPA5143393 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,427.00
GST (18%): ₹ 7,096.86
Total Price: ₹ 46,523.86
Antigen
PAX2a
Classification
Polyclonal
Conjugate
Unconjugated
Gene Alias
FSGS7; Opdc; optic disc coloboma; paired box 2; paired box gene 2; paired box homeotic gene 2; paired box protein Pax-2; PAPRS; PAX2; Pax-2
Immunogen
Recombinant protein encompassing a sequence within the center region of zebrafish Pax2a. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (PFA fixed), Western Blot
Concentration
1.03 mg/mL
Formulation
PBS with 20% glycerol and 0.025% Proclin 300; pH 7
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Target Species
Fish, Zebrafish
Product Type
Antibody
Isotype
IgG
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Description
- Store as concentrated solution
- Centrifuge briefly prior to opening vial
- Positive control: 2dpf zebrafish embryos, 36 hpf zebrafish embryos
- The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development
- Pax family members possess a DNA-binding domain encoded by the paired box
- Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program
- Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor
- During embryogenesis, Pax-2 is expressed in the developing kidney
- In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures
- Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors
- Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors
- Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.