BUBR1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA517137-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA517137 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
BUBR1
Classification
Polyclonal
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
O60566
Gene Symbols
BUB1B
Immunogen
Synthetic peptide corresponding to amino acid sequence surrounding Lys370 of human Bub1b
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Gene
BUB1B
Gene Alias
AU045529; BUB1 budding uninhibited by benzimidazoles 1 homolog beta; BUB1 mitotic checkpoint serine/threonine kinase B; Bub1A; Bub1b; BUB1B, mitotic checkpoint serine/threonine kinase; BUB1beta; BUBR1; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog beta; budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae); hBub1; hBUBR1; MAD3/BUB1-related protein kinase; MAD3L; Mitotic checkpoint kinase MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MVA1; Protein SSK1; SSK1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
701
Content And Storage
-20°C
Form
Liquid
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Description
- It is not recommended to aliquot this antibody
- BUBR1 is a member of the Ser/Thr protein kinase family
- It is a component of the mitotic checkpoint that delays anaphase until all chromosome are properly attached to the mitotic spindle
- Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations
- Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1
- They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions
- hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early
- BUBR1 has been detected in human cancers
- It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.