PIPA519314
Cullin 2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA519314-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA519314 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Cullin 2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cul2
Gene Alias
1300003D18Rik; 4932411N15Rik; AI327301; CUL2; CUL-2; cullin 2; cullin-2; MGC131970; mKIAA4106; OTTHUMP00000019437; testis secretory sperm-binding protein Li 238E
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
71745, 8453
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q13617, Q9D4H8
Gene Symbols
Cul2
Immunogen
Synthetic peptide sequence (QYIERSQASADE) corresponding to the C-terminus amino acids of CUL2
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with bovine, canine, human and rat based on sequence homology
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000
- Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins
- ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346)
- May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme
- The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1
- The functional specificity of the ECS complex depends on the substrate recognition component
- ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF)
- [UniProt]