TSC2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520132-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA520132 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
TSC2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TSC2
Gene Alias
LAM; Nafld; OTTHUMP00000198394; PPP1R160; protein phosphatase 1, regulatory subunit 160; Rc; renal carcinoma; Tcs2; Tsc2; TSC4; Tuberin; tuberous sclerosis 2; tuberous sclerosis 2 homolog protein; tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22084, 7249
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
P49815, Q61037
Gene Symbols
TSC2
Immunogen
A 15 amino acid peptide from near the carboxy terminus of human TSC2.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is L1210 cell lysate
- PA5-20132 can be used with blocking peptide PEP-0250
- TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2), is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors
- TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin
- Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin, and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway
- TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors
- Interaction between TSC1 and TSC2 may facilitate vesicular docking
- TSC2 specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth
- Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma
- Alternative splicing results in transcript variants of three different isoforms of TSC2.