APH1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520317-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA520317 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
APH1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
APH1A
Gene Alias
6530402N02Rik; anterior pharynx defective 1 homolog A; anterior pharynx defective 1a homolog; anterior pharynx defective 1a homolog (C. elegans); APH1; APH-1; aph-1 homolog A, gamma secretase subunit; aph-1 homolog A, gamma-secretase subunit; Aph1a; APH-1a; APH1A gamma secretase subunit; Aph-1alpha; CGI-78; Gamma-secretase subunit APH-1A; hypothetical protein LOC539247; presenilin-stabilization factor; PSF; RGD1311546; RP4-790G17.3; UNQ579/PRO1141
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
226548, 51107
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q8BVF7, Q96BI3
Gene Symbols
APH1A
Immunogen
A 13 amino acid peptide from near the amino terminus of human APH1a.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Despite its predicted molecular weight, APH1 often migrates at aberrant locations in SDS-PAGE
- A suggested positive control is RAW264.7 cell lysate
- PA5-20317 can be used with blocking peptide PEP-0437
- APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein)
- The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist
- APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.