NPAS3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA520364-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA520364 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
NPAS3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NPAS3
Gene Alias
4930423H22Rik; Basic-helix-loop-helix-PAS protein MOP6; bHLHe12; Class E basic helix-loop-helix protein 12; member of PAS protein 6; MOP6; neuronal PAS domain protein 3; neuronal PAS domain-containing protein 3; Neuronal PAS3; NPAS3; PAS domain-containing protein 6; PASD6
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
27386, 299016, 64067
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q8IXF0, Q9QZQ0
Gene Symbols
NPAS3
Immunogen
a 28 amino acid peptide from near the amino terminus of human NPAS3.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is SK-N-SH cell lysate
- PA5-20364 can be used with blocking peptide PEP-0484
- Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia
- It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region
- NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities
- Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin
- These results demonstrate the essential role played by NPAS3 during structural and functional brain development
- At least three isoforms of NPAS3 are known to exist.